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Literature summary for 2.4.1.274 extracted from

  • Chatterjee, S.; Castiglione, E.
    UDPgalactose:glucosylceramide beta1->4-galactosyltransferase activity in human proximal tubular cells from normal and familial hypercholesterolemic homozygotes (1987), Biochim. Biophys. Acta, 923, 136-142.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Cutscum maximal activity in a detergent mixture, Triton X-100/Cutscum (1:2, v/v), 0.1 mg/ml Homo sapiens
Triton X-100 maximal activity in a detergent mixture, Triton X-100/Cutscum (1:2, v/v), 0.1 mg/ml Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
UDP-galactose pH 6.8, 37°C Homo sapiens
0.003
-
beta-D-glucosyl-(1<->1)-ceramide pH 6.8, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ the enzyme is inactive without added metal ions. Maximal activity is obtained in the presence of 1.0 mM Mn2+/Mg2+ (1:1) Homo sapiens
Mn2+ optimum activity is obtained in the presence of 1.0 mM Mn2+/Mg2+ (1:1) Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose + beta-D-glucosyl-(1<->1)-ceramide Homo sapiens the enzyme is involved in the synthesis of several different major classes of glycosphingolipids UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
renal proximal tubule from normal and familial hypercholesterolemic homozygotes. Urinary proximal tubular cells from familial hypercholesterolemic homozygous patients contain glucosylceramide beta-1,4-galactosyltransferase activity 35% higher as compared to control cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + beta-D-glucosyl-(1<->1)-ceramide
-
Homo sapiens UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
?
UDP-galactose + beta-D-glucosyl-(1<->1)-ceramide the enzyme is involved in the synthesis of several different major classes of glycosphingolipids Homo sapiens UDP + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
?

Synonyms

Synonyms Comment Organism
UDPgalactose:glucosylceramide beta1->4-galactosyltransferase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at Homo sapiens

General Information

General Information Comment Organism
physiological function elevated glucosylceramide beta-1,4-galactosyltransferase activity may contribute to the storage of lactosylceramide urinary proximal tubular cells from familial hypercholesterolemic patients Homo sapiens