Application | Comment | Organism |
---|---|---|
synthesis | expression of different deoxysugar biosynthetic gene cassettes and the gene encoding a substrate-flexible glycosyltransferase DesVII in Streptomyces venezuelae YJ003 mutant strain bearing a deletion of a desosamine biosynthetic (des) gene cluster. The resulting recombinants produce macrolide antibiotic YC-17 analogs possessing unnatural sugars replacing native D-desosamine. These metabolites are D-quinovosyl-10-deoxymethynolide, L-rhamnosyl-10-deoxymethynolide, L-olivosyl-10-deoxymethynolide, and D-boivinosyl-10-deoxymethynolide | Streptomyces venezuelae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces venezuelae | Q9ZGH7 | - |
- |
Streptomyces venezuelae ATCC 15439 | Q9ZGH7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide | - |
Streptomyces venezuelae | dTDP + 10-deoxymethymycin | - |
? | |
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolide | - |
Streptomyces venezuelae ATCC 15439 | dTDP + 10-deoxymethymycin | - |
? | |
dTDP-D-boivinose + 10-deoxymethynolide | - |
Streptomyces venezuelae | dTDP + D-boivinosyl-10-deoxymethynolide | - |
? | |
dTDP-D-boivinose + 10-deoxymethynolide | - |
Streptomyces venezuelae ATCC 15439 | dTDP + D-boivinosyl-10-deoxymethynolide | - |
? | |
dTDP-D-quinovose + 10-deoxymethynolide | - |
Streptomyces venezuelae | dTDP + D-quinovosyl-10-deoxymethynolide | - |
? | |
dTDP-D-quinovose + 10-deoxymethynolide | - |
Streptomyces venezuelae ATCC 15439 | dTDP + D-quinovosyl-10-deoxymethynolide | - |
? | |
dTDP-L-olivose + 10-deoxymethynolide | - |
Streptomyces venezuelae | dTDP + L-olivosyl-10-deoxymethynolide | - |
? | |
dTDP-L-olivose + 10-deoxymethynolide | - |
Streptomyces venezuelae ATCC 15439 | dTDP + L-olivosyl-10-deoxymethynolide | - |
? | |
dTDP-L-rhamnose + 10-deoxymethynolide | - |
Streptomyces venezuelae | dTDP + L-rhamnosyl-10-deoxymethynolide | substitution with L-rhamnose results in better antibacterial activity than parent compound 10-deoxymethymycin | ? | |
dTDP-L-rhamnose + 10-deoxymethynolide | - |
Streptomyces venezuelae ATCC 15439 | dTDP + L-rhamnosyl-10-deoxymethynolide | substitution with L-rhamnose results in better antibacterial activity than parent compound 10-deoxymethymycin | ? |