Literature summary for 2.4.1.292 extracted from

Karlyshev, A.V.; Everest, P.; Linton, D.; Cawthraw, S.; Newell, D.G.; Wren, B.W.
The Campylobacter jejuni general glycosylation system is important for attachment to human epithelial cells and in the colonization of chicks (2004), Microbiology, 150, 1957-1964.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene pglH, cj1129,par of the pgl gene cluster	Campylobacter jejuni

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of pglH::kanr mutants, and complementation studies. The pglH::kanr mutant of strain 81116 has reduced colonization efficiency in a chick model. Mutation of pglH in strains 11168H and 81116 results in the reduced attachment to and invasion of Caco-2 cells. Reduction in attachment and invasion for strain 81116 are 23fold and 15fold, respectively, whereas the corresponding figures for strain 11168H are 6fold and and 5.4fold, respectively	Campylobacter jejuni

Organism

Organism	UniProt	Comment	Textmining
Campylobacter jejuni	-	and 11168H, hypermotile derivative of strains NCTC 11168 and 11828, gene pglH, cj1129	-
Campylobacter jejuni NCTC 11168	-	and 11168H, hypermotile derivative of strains NCTC 11168 and 11828, gene pglH, cj1129	-

General Information

General Information	Comment	Organism
malfunction	pglH mutants have significantly reduced ability to adhere to and invade human epithelial Caco-2 cells, the 81116 pglH mutant is also severely affected in its ability to colonize chicks	Campylobacter jejuni

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Release 2023.1 (January 2023)