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Literature summary for 2.4.1.313 extracted from

  • Hiruma, T.; Togayachi, A.; Okamura, K.; Sato, T.; Kikuchi, N.; Kwon, Y.; Nakamura, A.; Fujimura, K.; Gotoh, M.; Tachibana, K.; Ishizuka, Y.; Noce, T.; Nakanishi, H.; Narimatsu, H.
    A novel human beta1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAcbeta1-3GlcNAc (2004), J. Biol. Chem., 279, 14087-14095.
    View publication on PubMed
Search for more literature for 2.4.1.313

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
 x * 55000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein] Homo sapiens
-
 UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NCR0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
ovary
-
 Homo sapiens
-
prostate gland
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-
testis highest expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme shows no activity toward any glycolipid, Gal-beta-4-mitrophenyl, Gal-beta-O-4-nitrophenyl, Gal-NAc-alpha-benzyl, GalNAc-beta-4-nitrophenyl, Glc-alpha-4-nitrophenyl, GlcA-beta-4-nitrophenyl, Fuc-alpha-4-nitrophenyl, Xyl-alpha-4-nitrophenyl, Xyl-beta-4-nitrophenyl, Man-alpha-4-nitrophenyl, lactoside-benzyl, lactosylceramide, galactocenebroside type 1, paragloboside, globoside, Galbeta(1->4)GalNAc-alpha-4-nitrophenyl, Galbeta(1->3)GlcNAc-beta-4-nitrophenyl, and Galbeta(1->3)GalNAcalpha(core1)-4-nitrophenyl Homo sapiens ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]
-
 Homo sapiens UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[protein]
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + 4-nitrophenyl-beta-D-glucose 2% activity compared to GlcNAc-beta-benzyl Homo sapiens ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + calf fetuin the enzyme efficiently transfers GalNAc to N-glycans of fetal calf fetuin, which is treated with neuraminidase and beta-galactosidase Homo sapiens ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + Gal-beta(1->3)(GlcNAcbeta(1->6))GalNAcalpha1-O-4-nitrophenyl best acceptor substrate, 185% activity compared to GlcNAc-beta-benzyl Homo sapiens ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + Glc-NAcbeta(1->6)GalNAcalpha1-O-4-nitrophenyl 19% activity compared to GlcNAc-beta-benzyl Homo sapiens ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + GlcNAc-beta-benzyl 100% activity Homo sapiens ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + GlcNAcbeta(1->3)GalNAcalpha-4-nitrophenyl 8% activity compared to GlcNAc-beta-benzyl Homo sapiens UDP + GalNAcbeta(1->3)GlcNAcbeta(1->3)GalNAcalpha-4-nitrophenyl
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + GlcNAcbeta(1->4)GlcNAcbeta1-O-benzyl 29% activity compared to GlcNAc-beta-benzyl Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
beta1,3-N-acetylgalactosaminyltransferase-II
-
 Homo sapiens
beta3GalNAc-T2
-
 Homo sapiens