Literature summary for 2.4.1.322 extracted from

Losey, H.C.; Jiang, J.; Biggins, J.B.; Oberthuer, M.; Ye, X.Y.; Dong, S.D.; Kahne, D.; Thorson, J.S.; Walsh, C.T.
Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides (2002), Chem. Biol., 9, 1305-1314.

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Organism

Organism	UniProt	Comment	Textmining
Amycolatopsis orientalis	Q9AFC7	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dTDP-beta-L-vancosamine + devancosaminyl-vancomycin	natural substrate	Amycolatopsis orientalis	dTDP + vancomycin	-	?
additional information	by tandem reaction of both glucosyltransferase GtfE and L-vancosaminyltransferase GtfD, amino- or deoxy hybrid disaccharide chains can be built on both teicoplanin and vancomycin aglycone scaffolds	Amycolatopsis orientalis	?	-	?
UDP-4-epi-vancosamine + 4-deoxy-glucosyl-teicoplanin aglycone	-	Amycolatopsis orientalis	UDP + 4-epi-vancosaminyl-(1,2)-4-deoxy-coplanin heptapeptide	-	?
UDP-4-epi-vancosamine + devancosaminyl-vancomycin	-	Amycolatopsis orientalis	UDP + epivancomycin	epivancomycin is a hybrid teicoplanin/vancomycin glycopeptide	?

Synonyms

Synonyms	Comment	Organism
L-vancosaminyltransferase	-	Amycolatopsis orientalis

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Release 2023.1 (January 2023)