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Literature summary for 2.4.1.328 extracted from

  • Zhang, C.; Fu, Q.; Albermann, C.; Li, L.; Thorson, J.S.
    The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification (2007), Chembiochem, 8, 385-390.
    View publication on PubMed
Search for more literature for 2.4.1.328

Activating Compound

Activating Compound Comment Organism Structure
additional information no requirement for an auxiliary activator protein Saccharopolyspora erythraea

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Streptomyces lividans Saccharopolyspora erythraea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTDP-beta-L-mycarose + erythronolide B Saccharopolyspora erythraea the enzyme is involved in the erythromycin biosynthetic pathway dTDP + 3-beta-L-mycarosylerythronolide B
-
 r

Organism

Organism UniProt Comment Textmining
Saccharopolyspora erythraea
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharopolyspora erythraea

Storage Stability

Storage Stability Organism
-80°C, stable for more than three months Saccharopolyspora erythraea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dTDP-beta-L-mycarose + erythronolide B
-
 Saccharopolyspora erythraea dTDP + 3-beta-L-mycarosylerythronolide B
-
 r
dTDP-beta-L-mycarose + erythronolide B the enzyme is involved in the erythromycin biosynthetic pathway Saccharopolyspora erythraea dTDP + 3-beta-L-mycarosylerythronolide B
-
 r
additional information EryBV tolerates C5/C6 aglycon modifications and a small set of additional TDP-beta-L-sugars Saccharopolyspora erythraea ?
-
 ?

Synonyms

Synonyms Comment Organism
dTDP-D-mycarose glycosyltransferase
-
 Saccharopolyspora erythraea
EryBV
-
 Saccharopolyspora erythraea

General Information

General Information Comment Organism
physiological function the enzyme is involved in the erythromycin biosynthetic pathway Saccharopolyspora erythraea