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Literature summary for 2.4.1.331 extracted from

  • Perez, M.; Lombo, F.; Zhu, L.; Gibson, M.; Brana, A.F.; Rohr, J.; Salas, J.A.; Mendez, C.
    Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins (2005), Chem. Commun. (Camb. ), 2005, 1604-1606.
    View publication on PubMed
Search for more literature for 2.4.1.331

Application

Application Comment Organism
medicine generation of L- and D-stereoisomers of amicetose by combining sugar biosynthesis genes from four different antibiotic gene clusters and transfer of both sugars to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase to yield antitumor tetracenomycins Streptomyces olivaceus
synthesis generation of L- and D-stereoisomers of amicetose by combining sugar biosynthesis genes from four different antibiotic gene clusters and transfer of both sugars to the elloramycin aglycone by the sugar flexible ElmGT glycosyltransferase to yield antitumor tetracenomycins Streptomyces olivaceus

Organism

Organism UniProt Comment Textmining
Streptomyces olivaceus Q9F2F9
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Streptomyces olivaceus Tü2353 Q9F2F9
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NDP-D-amicetose + 8-demethyltetracenomycin C
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 Streptomyces olivaceus NDP + 8-demethyl-8-alpha-D-amicetyltetracenomycin C
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 ?
NDP-D-amicetose + 8-demethyltetracenomycin C
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 Streptomyces olivaceus Tü2353 NDP + 8-demethyl-8-alpha-D-amicetyltetracenomycin C
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 ?
NDP-L-amicetose + 8-demethyltetracenomycin C
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 Streptomyces olivaceus NDP + 8-demethyl-8-alpha-L-amicetyltetracenomycin C
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 ?
NDP-L-amicetose + 8-demethyltetracenomycin C
-
 Streptomyces olivaceus Tü2353 NDP + 8-demethyl-8-alpha-L-amicetyltetracenomycin C
-
 ?