Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CaCl2 | 7 mM, 2fold increase in activity | Cryptococcus neoformans | |
EDTA | maximal activity at 50 mM | Cryptococcus neoformans | |
MgCl2 | 5 mM, 3fold increase in activity | Cryptococcus neoformans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
caspofungin | 50% inhibition at 0.00013 mg/ml | Aspergillus fumigatus | |
caspofungin | 50% inhibition at 0.016 mg/ml | Cryptococcus neoformans | |
caspofungin | 50% inhibition at 0.004 mg/ml | Neurospora crassa | |
caspofungin | 50% inhibition at 0.00013 mg/ml | Saccharomyces cerevisiae | |
cilofungin | 50% inhibition at 0.064 mg/ml | Cryptococcus neoformans |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | optimization of in vitro assay conditions | Cryptococcus neoformans | |
0.21 | - |
UDP-glucose | pH 7.75 | Cryptococcus neoformans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus fumigatus | - |
- |
- |
Cryptococcus neoformans | - |
- |
- |
Neurospora crassa | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucose + (1,3-beta-D-glucosyl)n | - |
Saccharomyces cerevisiae | UDP + (1,3-beta-D-glucosyl)n+1 | - |
? | |
UDP-glucose + (1,3-beta-D-glucosyl)n | - |
Neurospora crassa | UDP + (1,3-beta-D-glucosyl)n+1 | - |
? | |
UDP-glucose + (1,3-beta-D-glucosyl)n | - |
Cryptococcus neoformans | UDP + (1,3-beta-D-glucosyl)n+1 | - |
? | |
UDP-glucose + (1,3-beta-D-glucosyl)n | - |
Aspergillus fumigatus | UDP + (1,3-beta-D-glucosyl)n+1 | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.75 | - |
- |
Cryptococcus neoformans |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00017 | - |
caspofungin | pH 7.75, 25°C | Cryptococcus neoformans | |
0.00067 | - |
caspofungin | pH 7.75, 25°C | Saccharomyces cerevisiae | |
0.0022 | - |
caspofungin | pH 7.75, 25°C | Neurospora crassa | |
0.0041 | - |
caspofungin | pH 7.75, 25°C | Aspergillus fumigatus | |
0.022 | - |
cilofungin | pH 7.75, 25°C | Cryptococcus neoformans |