Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2,6-difluoro-phenyl)-carbamic acid 3-(4-benzothiazol-2-yl-piperazine-1-yl)-propyl ester | The piperazine propanol derivative GS1578 was identified as a potent inhibitor against 1,3-beta-D-glucan synthase, IC50: 0.16 microM. | Candida albicans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | 1,3-beta-D-glucan synthase catalyses the synthesis of 1,3-beta-D-glucan, the most abundant component of the fungal cell wall. | Candida albicans | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | 1,3-beta-D-glucan synthase is composed of a putative catalytic subunit with sixteen putative transmembrane domains and a regulatory subunit encoded by CaFKS1/GSC1and CaRHO1 respectively. | Candida albicans |
More | 1,3-beta-D-glucan synthase is composed of a putative catalytic subunit with sixteen putative transmembrane domains encoded by a pair of closely related genes, FKS1/GSC1/CWH53/ETG1/CND1/PBR1/YLR342W and FKS2/GSC2/G4074/YGRO32W and a regulatory subunit encoded by RHO1. | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
1,3-beta-D-glucan 3-beta-D-glucosyltransferase | - |
Saccharomyces cerevisiae |
1,3-beta-D-glucan 3-beta-D-glucosyltransferase | - |
Candida albicans |
1,3-beta-D-glucan synthase | - |
Saccharomyces cerevisiae |
1,3-beta-D-glucan synthase | - |
Candida albicans |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00016 | - |
The piperazine propanol derivative GS1578 was identified as a potent inhibitor against 1,3-beta-D-glucan synthase, IC50: 0.16 microM. | Candida albicans | (2,6-difluoro-phenyl)-carbamic acid 3-(4-benzothiazol-2-yl-piperazine-1-yl)-propyl ester |