Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the activity of GalT V promoter can be induced by epidermal growth factor, dominant active Ras, ERK1, JNK1, and constitutively active AKT | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | GalT V might represent a target in glioma therapy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, expresion analysis, stable overexpression of HA-tagged GalT V in astrocytes C8-D30 and glioma cell lines U87 and U251, expression of mutant enzymes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
Y268G | site-directed mutagenesis, the mutant enzyme is less active compared to the wild-type enzyme | Homo sapiens |
Y268G/Y294G | site-directed mutagenesis, the mutant enzyme is less active compared to the wild-type enzyme | Homo sapiens |
Y294G | site-directed mutagenesis, the mutant enzyme is less active compared to the wild-type enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | decreasing the expression of GalT V in glioma cells promotes apoptosis, inhibits the invasion and migration and the ability of tumor formation in vivo, and reduces the activation of AKT, the enzyme functions as a glioma growth activator, overview, contribution of GalT V in the activation of AKT and MAPK kinase, contribution of serum or EGF in the transcription regulation of the GalT V gene, overview | ? | - |
? | |
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide | Homo sapiens | the enzyme effectively galactosylates the GlcNAcbeta1,6Man arm of the highly branched N-glycans that are characteristic of glioma, overview | UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SHG-44 cell | glioma cell line | Homo sapiens | - |
U-251 cell | glioma cell line | Homo sapiens | - |
U-87MG cell | glioma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | decreasing the expression of GalT V in glioma cells promotes apoptosis, inhibits the invasion and migration and the ability of tumor formation in vivo, and reduces the activation of AKT, the enzyme functions as a glioma growth activator, overview, contribution of GalT V in the activation of AKT and MAPK kinase, contribution of serum or EGF in the transcription regulation of the GalT V gene, overview | Homo sapiens | ? | - |
? | |
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide | - |
Homo sapiens | UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide | - |
? | |
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide | the enzyme effectively galactosylates the GlcNAcbeta1,6Man arm of the highly branched N-glycans that are characteristic of glioma, overview | Homo sapiens | UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta1,4-galactosyltransferase V | - |
Homo sapiens |
GalT V | - |
Homo sapiens |