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Literature summary for 2.4.1.38 extracted from

  • Ramasamy, V.; Ramakrishnan, B.; Boeggeman, E.; Ratner, D.M.; Seeberger, P.H.; Qasba, P.K.
    Oligosaccharide preferences of beta1,4-galactosyltransferase-I: crystal structures of Met340His mutant of human beta1,4-galactosyltransferase-I with a pentasaccharide and trisaccharides of the N-glycan moiety (2005), J. Mol. Biol., 353, 53-67.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant M340H enzymes in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
purified wild-type and M340H mutant enzymes in complex with pentasaccharide GlcNAcbeta1,2-Manalpha1,6 (GlcNAcbeta1,2-Manalpha1,3) and trisaccharide GlcNAcbeta1,4-GlcNAcbeta1,4-GlcNAc substrates, X-ray diffraction structure determination and analysis at 1.9-2.0 A resolution Homo sapiens

Protein Variants

Protein Variants Comment Organism
M340H site-directed mutagenesis, substrate binding structure in comparison to the wild-type enzyme, overview Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics, implications of the oligosaccharide structures on the kinetic parameters, overview Homo sapiens
0.01
-
N-acetyl-beta-D-glucosamine
-
Homo sapiens
0.06
-
GlcNAcbeta1,2-Manalpha1,6-Manbeta-OR
-
Homo sapiens
0.6
-
GlcNAcbeta1,2-Manalpha1,3-Manbeta-OR
-
Homo sapiens
0.71
-
GlcNAcbeta1,4-Manalpha1,3-Manbeta-OR
-
Homo sapiens
0.96
-
chitotriose
-
Homo sapiens
1.23
-
GlcNAcbeta1,2-Manalpha1,6 (GlcNAcbeta1,2-Manalpha1,3)Man
-
Homo sapiens
1.59
-
N-acetyl-beta-D-glucosaminyl-1,4-N-acetyl-beta-D-glucosamine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide Homo sapiens the enzyme transfers galactose from UDP-galactose to N-acetylglucosamine residues of the branched N-linked oligosaccharide chains of glycoproteins UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15291
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information complex penta-antennary N-glycan structure, detailed substrate binding structure analysis of the wild-type and mutant M340H enzymes, overview Homo sapiens ?
-
?
UDP-galactose + chitotriose GlcNAcbeta1,4-GlcNAcbeta1,4-GlcNAc Homo sapiens ?
-
?
UDP-galactose + GlcNAcbeta1,2-Manalpha1,3-Manbeta-OR an N-linked biantennary oligosaccharide chain, one antenna is attached to the 3-hydroxyl-(1,2-1,3-arm) group of mannose, which is beta-1,4-linked to an N-linked chitobiose, attached to the aspargine residue of a protein Homo sapiens ?
-
?
UDP-galactose + GlcNAcbeta1,2-Manalpha1,6 (GlcNAcbeta1,2-Manalpha1,3)Man
-
Homo sapiens ?
-
?
UDP-galactose + GlcNAcbeta1,2-Manalpha1,6-Manbeta-OR an N-linked biantennary oligosaccharide chain, one antenna is attached to the 3-hydroxyl-(1,2-1,6-arm) group of mannose, which is beta-1,4-linked to an N-linked chitobiose, attached to the aspargine residue of a protein Homo sapiens ?
-
?
UDP-galactose + GlcNAcbeta1,4-Manalpha1,3-Manbeta-OR an N-linked biantennary oligosaccharide chain, one antenna is attached to the 3-hydroxyl-(1,4-1,3-arm) group of mannose, which is beta-1,4-linked to an N-linked chitobiose, attached to the aspargine residue of a protein Homo sapiens ?
-
?
UDP-galactose + N-acetyl-beta-D-glucosamine
-
Homo sapiens UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminyl-1,4-N-acetyl-beta-D-glucosamine
-
Homo sapiens UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,4-N-acetyl-beta-D-glucosamine
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide
-
Homo sapiens UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
?
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide the enzyme transfers galactose from UDP-galactose to N-acetylglucosamine residues of the branched N-linked oligosaccharide chains of glycoproteins Homo sapiens UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide
-
?

Synonyms

Synonyms Comment Organism
beta1,4-galactosyltransferase-I
-
Homo sapiens
beta4Gal-T1
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.74
-
GlcNAcbeta1,2-Manalpha1,6 (GlcNAcbeta1,2-Manalpha1,3)Man
-
Homo sapiens
1.9
-
GlcNAcbeta1,2-Manalpha1,6-Manbeta-OR
-
Homo sapiens
2.47
-
GlcNAcbeta1,2-Manalpha1,3-Manbeta-OR
-
Homo sapiens
3.3
-
chitotriose
-
Homo sapiens
3.35
-
GlcNAcbeta1,4-Manalpha1,3-Manbeta-OR
-
Homo sapiens
3.6
-
N-acetyl-beta-D-glucosamine
-
Homo sapiens
4.81
-
chitotriose
-
Homo sapiens
4.82
-
N-acetyl-beta-D-glucosaminyl-1,4-N-acetyl-beta-D-glucosamine
-
Homo sapiens