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Literature summary for 2.4.1.38 extracted from

  • Wei, Y.; Zhou, F.; Ge, Y.; Chen, H.; Cui, C.; Li, Q.; Liu, D.; Yang, Z.; Wu, G.; Sun, S.; Gu, J.; Jiang, J.
    beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell (2010), Biochem. Biophys. Res. Commun., 396, 602-607.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
glioma cell
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Homo sapiens
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Synonyms

Synonyms Comment Organism
beta 1,4GalT V
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Homo sapiens
beta1,4-galactosyltransferase V
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Homo sapiens

General Information

General Information Comment Organism
malfunction decreasing the expression of beta1,4GalT V by RNA interference in glioma cells attenuates the formation of polylactosamine and inhibits the ability of tumor formation in vivo. Down-regulation of beta1,4GalT V depletes CD133-positive cells in glioma xenograft, and inhibits the self-renewal capacity and the tumorigenic potential of glioma-initiating cells Homo sapiens