Literature summary for 2.4.1.38 extracted from

Kouno, T.; Kizuka, Y.; Nakagawa, N.; Yoshihara, T.; Asano, M.; Oka, S.
Specific enzyme complex of beta-1,4-galactosyltransferase-II and glucuronyltransferase-P facilitates biosynthesis of N-linked human natural killer-1 (HNK-1) carbohydrate (2011), J. Biol. Chem., 286, 31337-31346.

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Protein Variants

Protein Variants	Comment	Organism
additional information	expression vectors bearing the luminal domains of beta4GalT-II and glucuronyltransferase show in GST-pulldown assays that the Golgi luminal domains are sufficient for the complex to form	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
beta-1,4-galactosyltransferase I	-	Homo sapiens
beta4GalT-II	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	in Neuro2a cells it is shown that beta4GalT-II associates with glucuronyltransferase. beta4GalT-II enhances kinetic efficacy of glucuronyltransferase. Co-expression of beta4GalT-II and glucuronyltransferase increase HNK-1 expression on various glycoproteins in N2a cells, including neural cell adhesion molecule	Homo sapiens
physiological function	the specific enzyme complex of beta4GalT-II with glucuronyltransferase plays an important role in the biosynthesis of human natural killer-1 carbohydrate	Homo sapiens

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Release 2023.1 (January 2023)