Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Schwann cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
beta-1,4-galactosyltransferase I | - |
Rattus norvegicus |
beta-1,4-GalT I | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | anti-TNFR1 antibody suppresses the expression of beta-1,4-GalT I, and TNF-alpha autocrine | down |
General Information | Comment | Organism |
---|---|---|
malfunction | silencing of beta-1,4-GalT I suppresses TNF-alpha autocrine, while overexpression of beta-1,4-GalT I promotes TNF-alpha autocrine in TNF-alpha-treated Schwann cells | Rattus norvegicus |
physiological function | beta-1,4-GalT I plays a positive role in the regulation of TNF-alpha-induced TNF-alpha secretion. It promotes the activation of ERK, JNK, and P38 MAP kinase signal pathways which subsequently enhance TNF-alpha secretion in TNF-alpha-treated Schwann cells | Rattus norvegicus |