Crystallization (Comment) | Organism |
---|---|
crystals of purified native enzyme are soaked with various combinations of UDP-GalNAc, UDP-Gal, UDP, and acceptor analogues alpha-L-fucosyl-1-2-beta-D-(3-deoxy)-galactosyl-O-R or alpha-L-fucosyl-1-2-beta-D-(3-amino)-galactosyl-O-R, ligands are solved in 7.5% PEG 4000, 15% glycerol, 75 mM N-[2-acetamido]-2-iminodiacetic acid, pH 7.5, 10 mM MnCl2, and 10 mM inhibitor, 3-4 days, X-ray diffraction structure determination and analysis at 2.1 A resolution | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-L-fucosyl-1-2-beta-D-(3-amino)-galactosyl-O-R | complex mode inhibitor, binding structure, Leu226 is involved by interacting with the C3-position group | Homo sapiens | |
alpha-L-fucosyl-1-2-beta-D-(3-deoxy)-galactosyl-O-R | competitive inhibitor, binding structure, Leu226 is involved by interacting with the C3-position group | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine + alpha-L-fucosyl-1-2-D-galactosyl-O-R | Homo sapiens | H-antigen disaccharide | UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1-2]-D-galactosyl-O-R | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16442 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-galactosamine + alpha-L-fucosyl-1-2-D-galactosyl-O-R | H-antigen disaccharide | Homo sapiens | UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1-2]-D-galactosyl-O-R | - |
? | |
UDP-N-acetyl-D-galactosamine + alpha-L-fucosyl-1-2-D-galactosyl-O-R | H-antigen disaccharide, Leu226 is responsible for substrate specificity for UDP-N-acetyl-D-galactosamine as donor substrate, acceptor substrate binding pocket structure, overview | Homo sapiens | UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1-2]-D-galactosyl-O-R | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ABO(H) blood group A glycosyltransferase | - |
Homo sapiens |
GTA | - |
Homo sapiens |