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Literature summary for 2.4.1.41 extracted from
- An acetylation site in lectin domain modulates the biological activity of polypeptide GalNAc-transferase-2 (2013), Biol. Chem., 394, 69-77.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Sf9 insect cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K521Q | the mutation enhances the carbohydrate specificity of lectin domain for alpha-GalNAc and results in reduced enzyme activity compared to the wild type enzyme | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzyl N-acetyl-alpha-D-galactosamine | - |
Homo sapiens |  |
| additional information | not inhibited by by D-glucose or UDP-N-acetyl-alpha-D-galactosamine | Homo sapiens | |
| N-acetyl-alpha-D-galactosamine | the acetylated enzyme is strongly inhibited by N-acetyl-alpha-D-galactosamine | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-alpha-D-galactosamine + polypeptide | Homo sapiens | - |
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Co2+-charged resin column chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-alpha-D-galactosamine + polypeptide | - |
Homo sapiens | UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| polypeptide GalNAc-transferase-2 | - |
Homo sapiens |
| ppGalNAc-T2 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 10 | - |
acetylated wild type enzyme, at pH 7.4 and 37°C | Homo sapiens | benzyl N-acetyl-alpha-D-galactosamine | |
| 15 | - |
mutant enzyme K521Q, at pH 7.4 and 37°C | Homo sapiens | N-acetyl-alpha-D-galactosamine | |
| 20 | - |
acetylated wild type enzyme, at pH 7.4 and 37°C | Homo sapiens | N-acetyl-alpha-D-galactosamine | |
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Release 2023.1 (January 2023)
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