Application | Comment | Organism |
---|---|---|
medicine | isoform GalNAc-T4 shows a stage-dependent expression at the different stages of colorectal cancer in 62 pair-matched tumor/normal tissues. GalNAc-T4 expression is significantly induced at stage I and II but not at stage III and IV. Overexpression of GalNAc-T4 in colorectal cancer cells enhances colony formation and sphere formation. Knockdown of GalNAc-T4 in colorectal cancer cells increases the cell migration and invasion, and leads to an epithelial-mesenchymal transition-like transition. Loss of GalNAc-T4 contributes to the dedifferentiation of colorectal cancer cells and high expression of GalNAc-T4 correlates to a good prognosis of patients | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N4A0 | isoform GALNT4 | - |
Synonyms | Comment | Organism |
---|---|---|
Galnt4 | - |
Homo sapiens |