Cloned (Comment) | Organism |
---|---|
expression in HEK 293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-epigallocatechin-3-gallate | time-dependent, irreversible | Homo sapiens | |
2,3-Dihydroxybenzoic acid | - |
Homo sapiens | |
2,4-dihydroxybenzoic acid | - |
Homo sapiens | |
2,5-dihydroxybenzoic acid | - |
Homo sapiens | |
3,4,5-Trihydroxybenzoic acid | gallic acid, time-dependent, irreversible | Homo sapiens | |
3,4,5-trimethoxybenzoic acid | - |
Homo sapiens | |
3,4-dihydroxybenzoic acid | - |
Homo sapiens | |
3,4-dimethoxybenzoic acid | - |
Homo sapiens | |
3,5-dimethoxy 4-hydroxybenzoic acid | syringic acid | Homo sapiens | |
ellagic acid | - |
Homo sapiens | |
methyl gallate | - |
Homo sapiens | |
propyl gallate | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | can replace Mn2+ for activation, optimum concentration is 10-15 mM | Homo sapiens | |
Mg2+ | can replace Mn2+ for activation, optimum concentration is 10-15 mM | Homo sapiens | |
Mn2+ | required for activation in vitro, optimum concentration is 10-15 mM | Homo sapiens | |
additional information | Cu2+ inactivates the enzyme | Homo sapiens | |
Zn2+ | can replace Mn2+ for activation, but shows only half the maximal activity, optimum concentration is 10-15 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q11130 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
fucosyltransferase 7 | - |
Homo sapiens |
fucosyltransferase VII | - |
Homo sapiens |
FucT VII | - |
Homo sapiens |
FucT-VII | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | 2,3-dihydroxybenzoic acid: above 0.200, presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose, 2,4-dihydroxybenzoic acid: above 0.200, presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose, 3,5-dimethoxy 4-hydroxybenzoic acid: above 0.200, presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose, 3,4-dimethoxybenzoic acid: above 0.200, presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose, 3,4,5-trimethoxybenzoic acid: above 0.200, presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose | Homo sapiens | |
0.00006 | - |
3,4,5-Trihydroxybenzoic acid | presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose | Homo sapiens | |
0.0007 | - |
(-)-epigallocatechin-3-gallate | presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose | Homo sapiens | |
0.0012 | - |
ellagic acid | presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose | Homo sapiens | |
0.0022 | - |
(-)-epigallocatechin-3-gallate | 60 min assay, no pre-incubation | Homo sapiens | |
0.0022 | - |
(-)-epigallocatechin-3-gallate | overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose, MnCl2 omitted in the overnight pre-incubation mixture | Homo sapiens | |
0.0054 | - |
3,4,5-Trihydroxybenzoic acid | overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose, MnCl2 omitted in the overnight pre-incubation mixture | Homo sapiens | |
0.008 | - |
3,4,5-Trihydroxybenzoic acid | 60 min assay, no pre-incubation | Homo sapiens | |
0.008 | - |
methyl gallate | presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose | Homo sapiens | |
0.045 | - |
propyl gallate | presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose | Homo sapiens | |
0.115 | - |
2,5-dihydroxybenzoic acid | presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose | Homo sapiens | |
0.137 | - |
3,4-dihydroxybenzoic acid | presence of MnCl2, overnight (15 h) pre-incubation of compound and enzyme before initiation of the reaction with GDP-fucose | Homo sapiens |