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Literature summary for 2.4.1.65 extracted from

  • Tefsen, B.; van Stijn, C.M.; van den Broek, M.; Kalay, H.; Knol, J.C.; Jimenez, C.R.; van Die, I.
    Chemoenzymatic synthesis of multivalent neoglycoconjugates carrying the helminth glycan antigen LDNF (2009), Carbohydr. Res., 344, 1501-1507.
    View publication on PubMed
Search for more literature for 2.4.1.65

Cloned(Commentary)

Cloned (Comment) Organism
plasmid ProtA-FucT-VI, encoding a soluble chimaeric protein consisting of a part of protein A fused to the catalytic domain of FucT-VI, transfected into Cos-7 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.14
-
 Fuc-alpha1-2Galbeta1-4GlcNAc-octyl
-
 Homo sapiens
0.27
-
 GalNAcbeta1-4GlcNAc-octyl
-
 Homo sapiens
3.6
-
 Galbeta1-4GlcNAc-4-nitrophenyl
-
 Homo sapiens
3.8
-
 GalNAcbeta1-4GlcNAc-diaminopimelyl
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Storage Stability

Storage Stability Organism
-80°C, several months Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-L-fucose + Fuc-alpha1-2Galbeta1-4GlcNAc-octyl
-
 Homo sapiens GDP + ?
-
 ?
GDP-L-fucose + Galbeta1-4GlcNAc-4-nitrophenyl
-
 Homo sapiens GDP + ?
-
 ?
GDP-L-fucose + GalNAcbeta1-4GlcNAc-diaminopimelyl
-
 Homo sapiens GDP + ?
-
 ?
GDP-L-fucose + GalNAcbeta1-4GlcNAc-octyl shows the highest catalytic activity as an acceptor substrate Homo sapiens GDP + ?
-
 ?

Synonyms

Synonyms Comment Organism
alpha1,3-fucosyltransferase VI
-
 Homo sapiens
FucT-VI
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function role in synthesis of parasitic GalNAc beta1-4(Fuc alpha1-3)GlcNAc beta-R antigen Homo sapiens