Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.66 extracted from

  • Leunis, J.C.; Smith, D.F.; Nwokoro, N.; Fishback, B.L.; Wu, C.; Jamieson, G.A.
    The distribution of collagen:glucosyltransferase in human blood cells and plasma (1980), Biochim. Biophys. Acta, 611, 79-86.
    View publication on PubMed
Search for more literature for 2.4.1.66

General Stability

General Stability Organism
bovine serum albumin, final concentration of 0.1%, enhances stability Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0074
-
 UDP-glucose
-
 Homo sapiens
2.75
-
 D-galactosylhydroxylysine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound and soluble forms in platelets, lymphocytes and granulocytes Homo sapiens 16020
-
soluble membrane-bound and soluble forms in platelets, lymphocytes and granulocytes Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ 10-15 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
5400fold from plasma, 4400fold from blood platelets Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood distribution, not: erythrocytes Homo sapiens
-
blood platelet
-
 Homo sapiens
-
granulocyte
-
 Homo sapiens
-
lymphocyte
-
 Homo sapiens
-
additional information not in erythrocytes Homo sapiens
-
plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0073
-
 purified enzyme from plasma Homo sapiens
0.1
-
 purified enzyme from blood platelets Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen
-
 Homo sapiens UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen
-
 ?
UDP-glucose + D-galactosylhydroxylysine in vitro Homo sapiens UDP + 1,2-D-glucosyl-D-galactosylhydroxylysine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Homo sapiens