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Literature summary for 2.4.1.66 extracted from

  • Risteli, M.; Ruotsalainen, H.; Salo, A.M.; Sormunen, R.; Sipilae, L.; Baker, N.L.; Lamande, S.R.; Vimpari-Kauppinen, L.; Myllylae, R.
    Reduction of lysyl hydroxylase 3 causes deleterious changes in the deposition and organization of extracellular matrix (2009), J. Biol. Chem., 284, 28204-28211.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information A195G/A434G/C882T/A1011G, reduced amount of LH3 in humans with epidermolysis bullosa simplex, only 30% GGT activity in cell lysate, only 40% GGT activity in the culture medium Homo sapiens
additional information MEF+/-, lysyl hydroxylase 3 knock-out mice, only 80% GGT activity in cell lysate, only 5% GGT activity in the culture medium Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens O60568
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cell lysate
-
Mus musculus
-
cell lysate
-
Homo sapiens
-
culture medium
-
Mus musculus
-
culture medium
-
Homo sapiens
-
embryonic fibroblast cell line
-
Mus musculus
-
fibroblast
-
Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens 67% expression of LH3 in humans with epidermolysis bullosa simplex down
Mus musculus decrease in lysyl hydroxylase 3 in LH3 knock-out mice down

General Information

General Information Comment Organism
physiological function organization of the extracellular matrix and cytoskeleton Mus musculus
physiological function organization of the extracellular matrix and cytoskeleton Homo sapiens