Cloned (Comment) | Organism |
---|---|
expressed in MDCK, COS-7 and HT-1080 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D187A/D189A/D190A/D191A | the mutant shows unreduced lysyl hydroxylase 3 activity | Homo sapiens |
D669A | the mutant shows no lysyl hydroxylase 3 activity | Homo sapiens |
N23S | lysyl hydroxylase 3 activity is reduced by nearly 50% | Homo sapiens |
R729A | the mutant shows no lysyl hydroxylase 3 activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
endoplasmic reticulum | secretion of the enzyme from the endoplasmic reticulum to the extracellular space occurs via two secretory pathways, which generate two glycoforms. Enzyme molecules found in the cell medium are secreted through the Golgi complex, and the secretion is dependent on lysyl hydroxylase 3 glycosyltransferase activity. Enzyme found on the cell surface bypasses the Golgi complex | Homo sapiens | 5783 | - |
extracellular | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | lysyl hydroxylase 3 is a post-translational modification enzyme with lysyl hydroxylase collagen galactosyltransferase, and glucosyltransferase activities | Homo sapiens | ? | - |
? | |
UDP-glucose + calf skin gelatin | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LH3 | - |
Homo sapiens |
lysyl hydroxylase | - |
Homo sapiens |