KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.027 | - |
GDP-L-fucose | H-gene encoded enzyme | Homo sapiens | |
0.108 | - |
GDP-L-fucose | Se-encoded enzyme | Homo sapiens | |
1.4 | - |
lacto-N-biose I | Se-gene encoded enzyme | Homo sapiens | |
1.4 | - |
Galbeta(1-3)GalNAc | Se-gene encoded enzyme | Homo sapiens | |
1.4 | - |
lacto-N-tetraose | Se-gene encoded enzyme | Homo sapiens | |
1.9 | - |
N-acetyl-beta-lactosamine | H-gene encoded enzyme | Homo sapiens | |
2.1 | - |
lactose | H-gene encoded enzyme | Homo sapiens | |
2.2 | - |
lacto-N-tetraose | H-gene encoded enzyme | Homo sapiens | |
2.3 | - |
Galbeta(1-3)GalNAc | Se-gene encoded enzyme | Homo sapiens | |
2.9 | - |
beta-D-galactose | H-gene encoded enzyme | Homo sapiens | |
2.9 | - |
Galbeta(1-3)GalNAc | H-gene encoded enzyme | Homo sapiens | |
3 | - |
phenyl-beta-D-galactoside | H-gene encoded enzyme | Homo sapiens | |
3.2 | - |
beta-D-galactose-beta-O-2-(2-carbomethoxyethylthio)ethyl | H-gene encoded enzyme | Homo sapiens | |
3.4 | - |
lacto-N-neotetraose | H-gene encoded enzyme | Homo sapiens | |
3.5 | - |
lacto-N-biose I | H-gene encoded enzyme | Homo sapiens | |
4.2 | - |
Galbeta1-6GalNAc | H-gene encoded enzyme | Homo sapiens | |
5.5 | - |
lactose | Se-gene encoded enzyme | Homo sapiens | |
5.5 | - |
lacto-N-neotetraose | Se-gene encoded enzyme | Homo sapiens | |
5.7 | - |
N-acetyl-beta-lactosamine | Se-gene encoded enzyme | Homo sapiens | |
8.5 | - |
beta-D-galactose-beta-O-2-(2-carbomethoxyethylthio)ethyl | Se-gene encoded enzyme | Homo sapiens | |
11.4 | - |
phenyl-beta-D-galactoside | Se-gene encoded enzyme | Homo sapiens | |
24 | - |
beta-D-galactose | Se-gene encoded enzyme | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, enzyme from serum, SDS-PAGE under reducing conditions | Homo sapiens |
150000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
enzyme from serum | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood serum | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
188 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GDP-beta-L-fucose + beta-D-galactose | - |
Homo sapiens | ? | - |
? | |
GDP-L-fucose + beta-D-galactose-beta-O-2-(2-carbomethoxyethylthio)ethyl | - |
Homo sapiens | ? | - |
? | |
GDP-L-fucose + beta-D-galactosyl-R | - |
Homo sapiens | GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R | - |
? | |
GDP-L-fucose + D-galactose | - |
Homo sapiens | GDP + alpha-L-fucosyl-1,2-D-galactose | - |
? | |
GDP-L-fucose + Galbeta(1-3)GalNAc | - |
Homo sapiens | GDP + L-Fucalpha(1-2)Galbeta(1-3)GalNAc | - |
? | |
GDP-L-fucose + Galbeta(1-6)GalNAc | - |
Homo sapiens | GDP + L-Fucalpha(1-2)Galbeta(1-6)GalNAc | - |
? | |
GDP-L-fucose + lacto-N-biose 1 | - |
Homo sapiens | GDP + L-Fucalpha(1-2)Galbeta(1-3)GlcNAc | - |
? | |
GDP-L-fucose + lacto-N-neotetraose | - |
Homo sapiens | GDP + lacto-N-fucopentaose IV | - |
? | |
GDP-L-fucose + lacto-N-tetraose | - |
Homo sapiens | GDP + lacto-N-fucopentaose I | - |
? | |
GDP-L-fucose + lactose | - |
Homo sapiens | GDP + fucosyllactose | - |
? | |
GDP-L-fucose + N-acetyllactosamine | - |
Homo sapiens | GDP + alpha-L-fucosyl-1,2-N-acetyllactosamine | - |
? | |
GDP-L-fucose + phenyl-beta-D-galactoside | - |
Homo sapiens | GDP + phenyl 2-O-(alpha-L-fucopyranosyl)-beta-D-galactopyranoside | - |
? | |
additional information | secretor-type alpha1-2 fucosyltransferase shows significant lower affinity than the H-gene encoded enzyme for phenyl-beta-D-galactopyranoside and GDP-L-fucose as well as for type 1 oligosaccharide acceptors, Galbeta1-4GlcNAc. Type 1 acceptors, Galbeta1-3GlcNAc, and type 3 acceptors, Galbeta1-3GalNAc, are preferentially used by the secretor-type enzyme as compared with the H enzyme | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, enzyme from serum, SDS-PAGE under reducing conditions | Homo sapiens |