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Literature summary for 2.4.1.80 extracted from

  • Rittershaus, P.C.; Kechichian, T.B.; Allegood, J.C.; Merrill, A.H.; Hennig, M.; Luberto, C.; Del Poeta, M.
    Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans (2006), J. Clin. Invest., 116, 1651-1659.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae Cryptococcus neoformans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + N-acylsphingosine Cryptococcus neoformans GCS is a key regulator of pathogenicity of Cryptococcus neoformans by ensuring cell cycle progression and growth of fungal cells in environments characterized by neutral/alkaline pH and physiological concentrations of CO2. Since these environments are characteristically found in the lung alveolar spaces, GCS regulates survival of Cryptococcus neoformans upon inhalation through the respiratory tract, with important implications for the dissemination of fungal cells to the brain and the development of meningo-encephalitis UDP + D-glucosyl-N-acylsphingosine
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 ?

Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans Q58FH5
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + N-acylsphingosine GCS is a key regulator of pathogenicity of Cryptococcus neoformans by ensuring cell cycle progression and growth of fungal cells in environments characterized by neutral/alkaline pH and physiological concentrations of CO2. Since these environments are characteristically found in the lung alveolar spaces, GCS regulates survival of Cryptococcus neoformans upon inhalation through the respiratory tract, with important implications for the dissemination of fungal cells to the brain and the development of meningo-encephalitis Cryptococcus neoformans UDP + D-glucosyl-N-acylsphingosine
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 ?
UDP-glucose + N-acylsphingosine Cryptococcus neoformans Gcs1 expressed in Saccharomyces cerevisiae is unable to recognize 7-nitro-2-1,3-benzoxadiazol-4-yl-ceramide analogs as substrates Cryptococcus neoformans UDP + D-glucosyl-N-acylsphingosine
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 ?

Synonyms

Synonyms Comment Organism
GCS1
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 Cryptococcus neoformans