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Literature summary for 2.4.1.80 extracted from

  • Ruckhaeberle, E.; Karn, T.; Hanker, L.; Gaetje, R.; Metzler, D.; Holtrich, U.; Kaufmann, M.; Rody, A.
    Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer (2009), J. Cancer Res. Clin. Oncol., 135, 81-90.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + ceramide
-
Homo sapiens UDP + glucosylceramide
-
ir

Synonyms

Synonyms Comment Organism
GCS
-
Homo sapiens
glucosylceramide synthase
-
Homo sapiens
Ugcg
-
Homo sapiens

General Information

General Information Comment Organism
malfunction In an analysis of microarray data of in a large cohort of 1681 breast tumors, there was a benefit for disease free survival for patients with tumors displaying low levels of GCS expression, especially in tumors with a positive estrogen receptor (ER) status. Homo sapiens