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Literature summary for 2.4.1.83 extracted from

  • Baksi, K.; Tavarez-Pagan, J.J.; Martinez, J.A.; Banerjee, D.K.
    Unique structural motif supports mannosylphospho dolichol synthase: an important angiogenesis regulator (2008), Curr. Drug Targets, 9, 262-271.
    View publication on PubMed
Search for more literature for 2.4.1.83

Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cAMP capillary endothelial cells treated with the cAMP enhancer 8-bromo-cAMP show a 20% and 30% higher activity after 24h and 32h, respectively Bos taurus

Application

Application Comment Organism
medicine increased DPMS activity through protein phosphorylation is a driving force for angiogenesis Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein alignment of the amino acid sequence of bDPM1 with that of Homo sapiens, Schizosaccharomyces pombe, Saccharomyces cerevisiae and Ustilago maydis indicates the presence of a cAMP-dependent phosphorylation motif Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-mannose + dolichyl phosphate
-
 Bos taurus GDP + dolichyl D-mannosyl phosphate
-
 ?

Synonyms

Synonyms Comment Organism
bDPM1
-
 Bos taurus
DPMS
-
 Bos taurus
mannosylphospho dolichol synthase
-
 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Bos taurus