Literature summary for 2.4.1.87 extracted from

Deriy, L.; Ogawa, H.; Gao, G.P.; Galili, U.
In vivo targeting of vaccinating tumor cells to antigen-presenting cells by a gene therapy method with adenovirus containing the alpha1,3galactosyltransferase gene (2005), Cancer Gene Ther., 12, 528-539.

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Application

Application	Comment	Organism
medicine	protection against tumors by immunization with AdaGT-transduced tumor cells (replication deficient adenovirus containing the alpha1,3GT gene) is studied in alpha1,3GT knockout (KO) mice, challenged with the highly tumorigenic BL6 melanoma cells. These mice lack alpha-gal epitopes and can produce anti-Gal. Immunization of KO mice with AdaGT-transduced BL6 cells protects many of the mice against challenge with live BL6 cells lacking alpha-gal epitopes. Immunization with AdalphaGT transduced autologous tumor cells may serve as adjuvant immunotherapy delivered after completion of standard therapy	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
alpha1,3galactosyltransferase	-	Mus musculus
alpha1,3GT	-	Mus musculus

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Release 2023.1 (January 2023)