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Literature summary for 2.4.1.87 extracted from

  • Saethre, M.; Schneider, M.K.; Lambris, J.D.; Magotti, P.; Haraldsen, G.; Seebach, J.D.; Mollnes, T.E.
    Cytokine secretion depends on Galalpha (1,3)Gal expression in a pig-to-human whole blood model (2008), J. Immunol., 180, 6346-6353.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information porcine aortic endothelial cells from control (Gal+/+) and Gal-deficient (Gal-/-) pigs are incubated with human lepirudin anticoagulated whole blood from healthy donors. E-selectin expression is measured by flow cytometry. The C3 inhibitor compstatin and a C5aR antagonist is used to study the role of complement. Gal+/+ porcine aortic endothelial cells incubated with human whole blood show a marked complement C5b-9 dependent up-regulation of E-selectin and secretion of porcine IL-6 and IL-8. Gal-/- cells respond with weak E-selectin and cytokine expression so that the role of complement can not be determined. Human IL-6, IL-8, IFN-gamma, MIP-1alpha, MIP-1beta, eotaxin, and RANTES are detected in the Gal+/+ system, but no responses is seen in the Gal-/- system Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
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-
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Synonyms

Synonyms Comment Organism
alpha-1,3-galactosyltransferase
-
 Sus scrofa
alpha3GT
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 Sus scrofa