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Literature summary for 2.4.1.92 extracted from

  • Miyata, M.; Ichihara, M.; Tajima, O.; Sobue, S.; Kambe, M.; Sugiura, K.; Furukawa, K.; Furukawa, K.
    UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor alpha and interleukin 6 (2014), Biochem. Biophys. Res. Commun., 445, 504-510.
    View publication on PubMed
Search for more literature for 2.4.1.92

Cloned(Commentary)

Cloned (Comment) Organism
gene B4GALNT1, quantitative enzyme expression analysis, mRNA expressions of glycosyltransferases by qRT-PCR in melanocytes and melanoma lines, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 Homo sapiens
-
 UDP + ganglioside GM2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q00973 gene B4GALNT1
-

Source Tissue

Source Tissue Comment Organism Textmining
melanocyte
-
 Homo sapiens
-
melanoma cell high expression level Homo sapiens
-
MeWo cell
-
 Homo sapiens
-
SK-MEL-23 cell
-
 Homo sapiens
-
SK-MEL-28 cell
-
 Homo sapiens
-
SK-MEL-37 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3
-
 Homo sapiens UDP + ganglioside GM2
-
 ?

Synonyms

Synonyms Comment Organism
beta-1,4 N-acetylgalactosaminyltransferase 1 UniProt Homo sapiens
GM2/GD2 synthase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression levels are reduced after UVB irradiation in SK-MEL-28 melanoma cells down
Homo sapiens tumor necrosis factor alpha and interleukin 6 do not affect the enzyme expression in in melanocytes additional information
Homo sapiens GM2/GD2 synthase expression is slightly increased in UVB-irradiated melanocytes, except for SK-MEL-28 cells up

General Information

General Information Comment Organism
metabolism the enzyme is part of the biosynthetic pathway of glycosphingolipids, overview Homo sapiens
additional information UVB-irradiation of keratinocytes induces melanoma-associated ganglioside GM2/GD2 synthase gene in melanocytes via secretion of tumor necrosis factor alpha and interleukin 6 Homo sapiens