Literature summary for 2.4.1.B62 extracted from

Bobo, L.D.; El Feghaly, R.E.; Chen, Y.S.; Dubberke, E.R.; Han, Z.; Baker, A.H.; Li, J.; Burnham, C.A.; Haslam, D.B.
MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammation (2013), Infect. Immun., 81, 713-722.

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Application

Application	Comment	Organism
medicine	phosphorylated mitogen-activated protein kinase MK-2 is activated by toxins TcdA and TcdB and regulates the expression of proinflammatory cytokines. Activation of p38-MK2 in infected animals and humans suggests that this pathway is a key driver of intestinal inflammation in patients with Clostridium difficile infection	Clostridioides difficile

Organism

Organism	UniProt	Comment	Textmining
Clostridioides difficile	-	-	-

General Information

General Information	Comment	Organism
physiological function	phosphorylated mitogen-activated protein kinase MK-2 is activated by toxins TcdA and TcdB and regulates the expression of proinflammatory cytokines. Activation of p38-MK2 in infected animals and humans suggests that this pathway is a key driver of intestinal inflammation in patients with Clostridium difficile infection	Clostridioides difficile

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Release 2023.1 (January 2023)