Literature summary for 2.4.1.B62 extracted from

Mitchell, T.; Ketley, J.; Burdon, D.; Candy, D.; Stephen, J.
The effects of Clostridium difficile toxins A and B on membrane integrity and protein synthesis in intestinal cells in vivo and in vitro and in McCoy cells in vitro (1987), J. Med. Microbiol., 23, 205-210.

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Organism

Organism	UniProt	Comment	Textmining
Clostridioides difficile	-	-	-

General Information

General Information	Comment	Organism
physiological function	toxin A, toxin B or crude toxin preparations have no effect on membrane integrity of either intestinal cells or McCoy cells as judged by nucleotide leakage. Toxins A and B, on their own ortogether in crude preparations, have no effect on the rate of protein synthesis in isolated intestinal cells in vitro. Both toxins inhibit protein synthesis in McCoy cells, and inhibition of protein synthesis could be a causative factor in the development of cytopathic effects	Clostridioides difficile

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Release 2023.1 (January 2023)