Literature summary for 2.4.1.B62 extracted from

Nam, S.T.; Seok, H.; Kim, D.H.; Nam, H.J.; Kang, J.K.; Eom, J.H.; Lee, M.B.; Kim, S.K.; Park, M.J.; Chang, J.S.; Ha, E.M.; Shong, K.E.; Hwang, J.S.; Kim, H.
Clostridium difficile toxin A inhibits erythropoietin receptor-mediated colonocyte focal adhesion through inactivation of Janus Kinase-2 (2012), J. Microbiol. Biotechnol., 22, 1629-1635.

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Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
307000	-	x * 307000, SDS-PAGE	Clostridioides difficile

Organism

Organism	UniProt	Comment	Textmining
Clostridioides difficile	-	-	-
Clostridioides difficile VPI 10463	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Clostridioides difficile

Subunits

Subunits	Comment	Organism
?	x * 307000, SDS-PAGE	Clostridioides difficile

General Information

General Information	Comment	Organism
physiological function	toxin A significantly decreases activating phosphorylations of erythropoietin receptor EpoR and its downstream signaling molecules Janus kinase JAK-2 and signal transducer and activator of transcription STAT5. Inhibition of JAK2 by toxin A in colonocytes causes inactivation of EpoR, thereby enhancing the inhibition of focal contact formation and loss of tight junctions known to be associated with the enzymatic activity of toxin A	Clostridioides difficile

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Release 2023.1 (January 2023)