Application | Comment | Organism |
---|---|---|
medicine | important role in therapies for ameliorating the symptoms of cholestasis or for dissolving gallstones | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in HEK293T cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C121G | a polymorphic UGT3A1 variant containing a C121G substitution is catalytically inactive | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.049 | - |
ursodeoxycholate | pH 7.5, 37°C | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53000 | - |
x * 53000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + ursodeoxycholate | Homo sapiens | i.e. 3',7'-dihydroxy-5'-cholanoic acid. Important role in the metabolism and elimination of ursodeoxycholic acid | UDP + 7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastrointestinal tract | poor activity | Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | also transfers N-acetyl-D-glucosamine to 17alpha-estradiol, 17beta-estradiol, 4-nitrophenol and 1-naphthol | Homo sapiens | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + ursodeoxycholate | i.e. 3',7'-dihydroxy-5'-cholanoic acid. Important role in the metabolism and elimination of ursodeoxycholic acid | Homo sapiens | UDP + 7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate | - |
? | |
UDP-N-acetyl-D-glucosamine + ursodeoxycholate | i.e. 3',7'-dihydroxy-5'-cholanoic acid. The enzyme uses ursodeoxycholic acid and UDP N-acetylglucosamine in preference to other primary and secondary bile acids, and other UDP sugars such as UDP glucose, UDP glucuronic acid, UDP galactose, and UDP xylose | Homo sapiens | UDP + 7beta-(N-acetyl-D-glucosaminyl)-ursodeoxycholate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 53000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
UDP glycosyltransferase 3A1 | - |
Homo sapiens |
UGT3A1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |