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Literature summary for 2.4.2.1 extracted from

  • Pereira, H.M.; Rezende, M.M.; Castilho, M.S.; Oliva, G.; Garratt, R.C.
    Adenosine binding to low-molecular-weight purine nucleoside phosphorylase: the structural basis for recognition based on its complex with the enzyme from Schistosoma mansoni (2010), Acta Crystallogr. Sect. D, 66, 73-79.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with adenine, adenosine, inosine, and hypoxanthine to 1.4 A resolution Schistosoma mansoni

Inhibitors

Inhibitors Comment Organism Structure
adenosine binds to enzyme and behaves as a weak inhibitor of inosine phosphorolysis Schistosoma mansoni

Organism

Organism UniProt Comment Textmining
Schistosoma mansoni Q9BMI9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + phosphate
-
Schistosoma mansoni adenine + alpha-D-ribose 1-phosphate
-
?
inosine + phosphate
-
Schistosoma mansoni hypoxanthine + alpha-D-ribose 1-phosphate
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.082
-
pH 7.0 Schistosoma mansoni adenosine