Literature summary for 2.4.2.1 extracted from

Kamath, V.P.; Juarez-Brambila, J.J.; Morris, P.E.
Synthesis of labeled BCX-4208, a potent inhibitor of purine nucleoside phosphorylase (2009), Drug Test. Anal., 1, 125-127.

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Inhibitors

Inhibitors	Comment	Organism	Structure
7-[[(3R,4R)-4-hydroxy-3-(hydroxymethyl)pyrrolidin-2-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one	i.e. BCX-4208, mimics the charged ribosyl oxocarbenium ion formed during the transition state	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000000016	-	7-[[(3R,4R)-4-hydroxy-3-(hydroxymethyl)pyrrolidin-2-yl]methyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one	-	Homo sapiens

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Release 2023.1 (January 2023)