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Literature summary for 2.4.2.1 extracted from

  • Isaksen, G.V.; Hopmann, K.H.; Aqvist, J.; Brandsdal, B.O.
    Computer simulations reveal substrate specificity of glycosidic bond cleavage in native and mutant human purine nucleoside phosphorylase (2016), Biochemistry, 55, 2153-2162.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
N243D the mutation has dramatic effects on the substrate specificity, making 6-amino- and 6-oxopurines equally good as substrates and clearly favoring adenosine over inosine and guanosine Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
purine deoxyribonucleoside + phosphate Homo sapiens
-
purine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?
purine ribonucleoside + phosphate Homo sapiens
-
purine + alpha-D-ribose 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + phosphate
-
Homo sapiens adenine + alpha-D-ribose 1-phosphate
-
?
guanosine + phosphate
-
Homo sapiens guanine + alpha-D-ribose 1-phosphate
-
?
inosine + phosphate
-
Homo sapiens hypoxanthine + alpha-D-ribose 1-phosphate
-
r
purine deoxyribonucleoside + phosphate
-
Homo sapiens purine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?
purine ribonucleoside + phosphate
-
Homo sapiens purine + alpha-D-ribose 1-phosphate
-
?

Synonyms

Synonyms Comment Organism
PNP
-
Homo sapiens
purine nucleoside phosphorylase
-
Homo sapiens