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Literature summary for 2.4.2.10 extracted from
- Divalent metal ion activation of the yeast orotate phosphoribosyltransferase catalyzed reaction (1979), Biochemistry, 18, 3597-3604.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | inhibits Mg2+-activation | Saccharomyces cerevisiae |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | not activating | Saccharomyces cerevisiae | |
| Co2+ | not activating | Saccharomyces cerevisiae | |
| Mg2+ | requirement | Saccharomyces cerevisiae | |
| Mg2+ | mechanism | Saccharomyces cerevisiae | |
| Mn2+ | activation | Saccharomyces cerevisiae | |
| Mn2+ | mechanism | Saccharomyces cerevisiae | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
Budweiser brand | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate | mechanism | Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 40 | - |
- |
Saccharomyces cerevisiae |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -76°C, at least 6 months | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| orotate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Saccharomyces cerevisiae | orotidine 5'-phosphate + diphosphate | - |
r | |
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