Literature summary for 2.4.2.10 extracted from

Oeda, M.; Yoshida, K.; Sanada, Y.; Wada, Y.; Suzuki, T.; Mizuiri, H.; Konishi, K.; Shigematsu, H.; Tanabe, K.; Fukushima, M.
The expression profiles of orotate phosphoribosyltransferase and dihydropyrimidine dehydrogenase in gastric cancer and their clinical significance (2006), Oncol. Rep., 16, 1165-1172.

Search for more literature for 2.4.2.10

Application

Application	Comment	Organism
diagnostics	OPRT and DPD are valuable prognostic markers in gastric cancer	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate	Homo sapiens	the activating OPRT and its antagonist the catabolizing dihydropyrimidine dehydrogenase play important roles in 5-fluorouracil metabolism, overview	5-fluorouridine 5'-phosphate + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
gastric cancer cell	221 specimen, expression profile of the enzyme and its antagonist dihydropyrimidine dehydrogenase both active in 5-fluorouracil metabolism, the enzyme expression levels correlate, overview	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate	-	Homo sapiens	5-fluorouridine 5'-phosphate + diphosphate	-	?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate	the activating OPRT and its antagonist the catabolizing dihydropyrimidine dehydrogenase play important roles in 5-fluorouracil metabolism, overview	Homo sapiens	5-fluorouridine 5'-phosphate + diphosphate	-	?

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Release 2023.1 (January 2023)