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Literature summary for 2.4.2.12 extracted from

  • Dietrich, L.S.; Muniz, O.
    Inhibition of nicotinamide phosphoribosyltransferase by pyridine nucleotides (1972), Biochemistry, 11, 1691-1695.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-acetylpyridine weak, kinetics Rattus norvegicus
3-acetylpyridine adenine dinucleotide kinetics Rattus norvegicus
5-Fluoronicotinamide weak, kinetics Rattus norvegicus
6-aminonicotinamide weak, kinetics Rattus norvegicus
Alpha-NAD+ weak Rattus norvegicus
NAD+ kinetics Rattus norvegicus
NADH weak Rattus norvegicus
NADP+
-
Rattus norvegicus
NADPH weak Rattus norvegicus
nicotinamide hypoxanthine dinucleotide
-
Rattus norvegicus
nicotinamide mononucleotide kinetics Rattus norvegicus
nicotinamide mononucleotide-H2 strong, kinetics Rattus norvegicus
nicotinamide riboside kinetics Rattus norvegicus
nicotinate adenine dinucleotide weak Rattus norvegicus
Thionicotinamide weak, kinetics Rattus norvegicus
Thionicotinamide adenine dinucleotide
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
nicotinamide in the presence of ATP Rattus norvegicus
100
-
nicotinamide in the absence of ATP Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Rattus norvegicus
-
nicotinamide D-ribonucleotide + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.003
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
Rattus norvegicus nicotinamide D-ribonucleotide + diphosphate
-
?
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate beta-nicotinamide Rattus norvegicus nicotinamide D-ribonucleotide + diphosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP requirement Rattus norvegicus