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Literature summary for 2.4.2.12 extracted from

  • Clark, D.E.; Waszkowycz, B.; Wong, M.; Lockey, P.M.; Adalbert, R.; Gilley, J.; Clark, J.; Coleman, M.P.
    Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies (2016), Bioorg. Med. Chem. Lett., 26, 2920-2926.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2E)-1-(4-[[2-(4-fluorophenyl)-1,3-thiazol-4-yl]methyl]piperazin-1-yl)-3-(pyridin-3-yl)prop-2-en-1-one
-
Homo sapiens
(2E)-3-(pyridin-3-yl)-1-[4-[4-(trifluoromethoxy)benzyl]piperazin-1-yl]prop-2-en-1-one
-
Homo sapiens
(2E)-3-(pyridin-3-yl)-N-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)phenyl]prop-2-enamide
-
Homo sapiens
(2E)-N-[2-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-6-yl)oxy]ethyl]-3-(pyridin-3-yl)prop-2-enamide
-
Homo sapiens
(2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)prop-2-enamide
-
Homo sapiens
1-[2-(naphthalen-2-yloxy)ethyl]-3-(pyridin-3-ylmethyl)urea
-
Homo sapiens
1H-indol-2-yl(4-[[3-(pyridin-3-yl)-1H-pyrazol-5-yl]carbonyl]piperazin-1-yl)methanone
-
Homo sapiens
2-[4-[(4-chlorophenyl)sulfamoyl]phenoxy]-N-(pyridin-3-ylmethyl)acetamide
-
Homo sapiens
4-[([7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxo-3,4-dihydroquinazolin-6-yl]methyl)(prop-2-yn-1-yl)amino]-N-[(pyridin-3-yl)methyl]benzamide
-
Homo sapiens
4-[[(2E)-3-(pyridin-3-yl)prop-2-enoyl]amino]-N-(2,2,2-trifluoroethyl)benzamide
-
Homo sapiens
5-(3,4-dichlorobenzyl)-4-oxo-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
-
Homo sapiens
CHS828
-
Homo sapiens
FK866
-
Homo sapiens
N-(4-butylphenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide
-
Homo sapiens
N-[4-(1-propyl-1H-pyrazole-3-sulfonyl)phenyl]-2-(pyridin-3-yl)cyclopropane-1-carboxamide
-
Homo sapiens
N-[4-(phenylsulfonyl)benzyl]-5-(pyridin-3-yl)-1H-pyrazole-3-carboxamide
-
Homo sapiens
[4-(diphenylmethyl)piperazin-1-yl][5-(pyridin-3-yl)-1H-pyrazol-3-yl]methanone
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43490
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
?

Synonyms

Synonyms Comment Organism
Nampt
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000051
-
pH and temperature not specified in the publication Homo sapiens N-[4-(1-propyl-1H-pyrazole-3-sulfonyl)phenyl]-2-(pyridin-3-yl)cyclopropane-1-carboxamide
0.0000418
-
pH and temperature not specified in the publication Homo sapiens N-(4-butylphenyl)-2-(pyridin-3-yl)cyclopropanecarboxamide
0.000043
-
pH and temperature not specified in the publication Homo sapiens N-[4-(phenylsulfonyl)benzyl]-5-(pyridin-3-yl)-1H-pyrazole-3-carboxamide
0.00022
-
pH and temperature not specified in the publication Homo sapiens 4-[[(2E)-3-(pyridin-3-yl)prop-2-enoyl]amino]-N-(2,2,2-trifluoroethyl)benzamide
0.0002427
-
pH and temperature not specified in the publication Homo sapiens [4-(diphenylmethyl)piperazin-1-yl][5-(pyridin-3-yl)-1H-pyrazol-3-yl]methanone
0.00032
-
pH and temperature not specified in the publication Homo sapiens 5-(3,4-dichlorobenzyl)-4-oxo-N-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
0.00067
-
pH and temperature not specified in the publication Homo sapiens (2E)-3-(pyridin-3-yl)-N-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)phenyl]prop-2-enamide
0.00078
-
pH and temperature not specified in the publication Homo sapiens (2E)-3-(pyridin-3-yl)-1-[4-[4-(trifluoromethoxy)benzyl]piperazin-1-yl]prop-2-en-1-one
0.00094
-
pH and temperature not specified in the publication Homo sapiens (2E)-N-[2-[(2,2-dimethyl-2,3-dihydro-1-benzofuran-6-yl)oxy]ethyl]-3-(pyridin-3-yl)prop-2-enamide
0.0019
-
pH and temperature not specified in the publication Homo sapiens 2-[4-[(4-chlorophenyl)sulfamoyl]phenoxy]-N-(pyridin-3-ylmethyl)acetamide
0.0032
-
pH and temperature not specified in the publication Homo sapiens (2E)-1-(4-[[2-(4-fluorophenyl)-1,3-thiazol-4-yl]methyl]piperazin-1-yl)-3-(pyridin-3-yl)prop-2-en-1-one
0.0038
-
pH and temperature not specified in the publication Homo sapiens 1H-indol-2-yl(4-[[3-(pyridin-3-yl)-1H-pyrazol-5-yl]carbonyl]piperazin-1-yl)methanone
0.005
-
pH and temperature not specified in the publication Homo sapiens 1-[2-(naphthalen-2-yloxy)ethyl]-3-(pyridin-3-ylmethyl)urea