Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.12 extracted from

  • Hsu, C.P.; Yamamoto, T.; Oka, S.; Sadoshima, J.
    The function of nicotinamide phosphoribosyltransferase in the heart (2014), DNA Repair, 23, 64-68.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
FK866
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43490
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
?

Synonyms

Synonyms Comment Organism
Nampt
-
Homo sapiens
PBEF
-
Homo sapiens
pre-B-cell colony-enhancing factor
-
Homo sapiens

General Information

General Information Comment Organism
physiological function nicotinamide phosphoribosyltransferase is a rate-limiting enzyme in the NAD+ salvage pathway and plays an important role in controlling the level of NAD+ and the activity of Sirt1 in the heart and the cardiomyocytes therein. The enzyme protects the heart from ischemia and reperfusion injury by stimulating Sirt1 and autophagy Homo sapiens