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Literature summary for 2.4.2.14 extracted from

  • Tsuda, M.; Katunuma, N.; Weber, G.
    Rat liver glutamine 5-phosphoribosyl-1-pyrophosphate amidotransferase [EC 2.4.2.14]. Purification and properties (1979), J. Biochem., 85, 1347-1354.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
AMP no inhibition in the presence of 5-phospho-alpha-D-ribose 1-diphosphate at high concentrations Rattus norvegicus
GMP no inhibition in the presence of 5-phospho-alpha-D-ribose 1-diphosphate at high concentrations Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.24 1.5 L-glutamine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
195000
-
sucrose density gradient centrifugation Rattus norvegicus
200000
-
native PAGE Rattus norvegicus
215000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O Rattus norvegicus rate-limiting enzyme of purine biosynthesis L-glutamate + 5-phospho-beta-D-ribosylamine + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
heat treatment, acid precipitation, ammonium sulfate, ethanol, Sephadex G-150, DE-52 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.82
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O
-
Rattus norvegicus 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate
-
?
L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O rate-limiting enzyme of purine biosynthesis Rattus norvegicus L-glutamate + 5-phospho-beta-D-ribosylamine + diphosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5 8.5 broad, Tris or phosphate buffer, constant activity Rattus norvegicus