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Literature summary for 2.4.2.14 extracted from
- Binding of purine nucleotides to two regulatory sites results in synergistic feedback inhibition of glutamine 5-phosphoribosylpyrophosphate amidotransferase (1994), J. Biol. Chem., 269, 6784-6789.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K326Q | insensitive to inhibition by GMP, reduced synergistic inhibition | Escherichia coli |
| K326Q/P410W | binding of GMP and AMP is abolished resulting in loss of inhibition | Escherichia coli |
| P410W | reduced inhibition by AMP, strong synergistic inhibition by AMP and GMP | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | synergistic inhibition by AMP and GMP, binding of GMP to an allosteric i.e. A site and AMP to a proximal catalytic i. e. C site are necessary for synergistic inhibition | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
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