Literature summary for 2.4.2.18 extracted from

Ito, J.; Yanofsky, C.
Anthranilate synthetase, an enzyme specified by the tryptophan operon of Escherichia coli: Comparative studies on the complex and the subunits (1969), J. Bacteriol., 97, 734-742.

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Inhibitors

Inhibitors	Comment	Organism	Structure
L-tryptophan	transferase activity of component II is only inhibitable by L-tryptophan when the component is in the complex, this inhibition does not appear to depend upon the feedback-sensitive site of complex I	Escherichia coli

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.1	-	5-phospho-alpha-D-ribose 1-diphosphate	complex	Escherichia coli
0.2	-	5-phospho-alpha-D-ribose 1-diphosphate	component II	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate	Escherichia coli	enzyme of tryptophan biosynthesis	N-(5-phospho-D-ribosyl)-anthranilate + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	anthranilate synthetase complex consisting of 2 separate subunits: component I and II	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate	-	Escherichia coli	N-(5-phospho-D-ribosyl)-anthranilate + diphosphate	-	?
anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate	enzyme of tryptophan biosynthesis	Escherichia coli	N-(5-phospho-D-ribosyl)-anthranilate + diphosphate	-	?

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Release 2023.1 (January 2023)