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Literature summary for 2.4.2.19 extracted from
- Crystallization and properties of quinolinate phosphoribosyltransferase from hog liver (1980), Methods Enzymol., 66, 96-101.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | 2 mM, 25% inhibition | Sus scrofa |  |
| ATP | 2 mM, 82% inhibition | Sus scrofa | |
| Cu2+ | 1 mM, 87% inhibition | Sus scrofa | |
| Fe2+ | 1 mM, 93% inhibition | Sus scrofa | |
| Monoiodoacetic acid | 5 mM, 50% inhibition | Sus scrofa | |
| PCMB | 0.05 mM, complete inhibition | Sus scrofa | |
| Phthalic acid | competitive to quinolinate | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.12 | - |
quinolinate | - |
Sus scrofa | |
| 0.18 | - |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Sus scrofa | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | optimal Mg2+ concentration: 1 mM | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 33500 | - |
x * 33500, SDS-PAGE | Sus scrofa |
| 202000 | - |
equilibrium sedimentation | Sus scrofa |
| 210000 | - |
gel filtration | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | formation of a ternary complex consisting the enzyme, pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.05169 | - |
- |
Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Sus scrofa | nicotinate D-ribonucleotide + diphosphate + CO2 | i.e. beta-niacin mononucleotide | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 33500, SDS-PAGE | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.1 | - |
- |
Sus scrofa |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 10 | - |
Sus scrofa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.17 | - |
Phthalic acid | - |
Sus scrofa | |
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