Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutarate | 1 mM, 55% inhibition | Sus scrofa | |
acetic acid | 26% inhibition | Sus scrofa | |
aspartic acid | 1 mM, 37% inhibition | Sus scrofa | |
Citric acid | 1 mM, 89% inhibition | Sus scrofa | |
formic acid | 1 mM, 54% inhibition | Sus scrofa | |
Fumaric acid | 1 mM, 67% inhibition | Sus scrofa | |
L-Glutamic acid | 1 mM, 41% inhibition | Sus scrofa | |
L-Malic acid | 1 mM, 67% inhibition | Sus scrofa | |
Lactic acid | 1 mM, 29% inhibition | Sus scrofa | |
Maleic acid | 1 mM, 42% inhibition | Sus scrofa | |
oxaloacetic acid | 1 mM, 59% inhibition | Sus scrofa | |
succinic acid | 1 mM, 46% inhibition | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04 | - |
quinolinate | - |
Sus scrofa | |
0.14 | - |
5-phospho-alpha-D-ribose 1-diphosphate | - |
Sus scrofa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | absolute requirement for divalent cations. Mg2+ is most effective. Optimal concentrations are 4, 6 and 10 mM for 20, 40 and 100 mM sodium acetate/acetic acid buffer, pH 5.5 | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | enzyme contains 1% mannose | Sus scrofa |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.091 | - |
- |
Sus scrofa |
Storage Stability | Organism |
---|---|
0-4°C, crystalline enzyme is stable for at least 2 years | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Sus scrofa | nicotinate D-ribonucleotide + diphosphate + CO2 | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
- |
Sus scrofa |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
3 | 3.5 | 37°C, denatured abruptly | Sus scrofa |
4.5 | 9.5 | 37°C, 30 min, completely stable | Sus scrofa |