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Literature summary for 2.4.2.19 extracted from
- The crystal structure of human quinolinic acid phosphoribosyltransferase in complex with its inhibitor phthalic acid (2014), Proteins, 82, 405-414.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| apoenzyme and in complex with phthalic acid, sitting drop vapor diffusion method, using 50 mM MES pH 6.5, 0.1 M NaH2PO4, 0.1 M K H2PO4, and 1.6-2.1 M NaCl | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Phthalic acid | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
nicotinic acid mononucleotide + diphosphate + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q15274 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| nickel Sepharose column chromatography and Superdex 200 gel filtration | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| quinolinic acid + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | nicotinic acid mononucleotide + diphosphate + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | x-ray crystallography | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| QPRT | - |
Homo sapiens |
| quinolinic acid phosphoribosyltransferase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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