Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-bromo-9-(1,3-dihydroxy-2-propoxymethyl)adenine | strong | Mus musculus | |
2-bromo-9-(2-hydroxyethoxymethyl)adenine | - |
Mus musculus | |
2-chloro-9-(1,3-dihydroxy-2-propoxymethyl)adenine | strong | Mus musculus | |
2-chloro-9-(2-hydroxyethoxymethyl)adenine | - |
Mus musculus | |
2-iodo-9-(1,3-dihydroxy-2-propoxymethyl)adenine | strong | Mus musculus | |
2-iodo-9-(2-hydroxyethoxymethyl)adenine | - |
Mus musculus | |
9-(phosphonoalkyl)adenine | - |
Mus musculus | |
9-(phosphonoheptyl)adenine | - |
Mus musculus | |
9-[(1-Hydroxy-3-iodo-2-propoxy)methyl]adenine | - |
Homo sapiens | |
9-[(1-Hydroxy-3-iodo-2-propoxy)methyl]adenine | competitive | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-methylthioadenosine + phosphate | Mus musculus | involved in salvage of adenine and methionine from 5'-methylthioadenosine | adenine + 5-methylthio-D-ribose 1-phosphate | - |
? | |
5'-methylthioadenosine + phosphate | Homo sapiens | involved in salvage of adenine and methionine from 5'-methylthioadenosine | adenine + 5-methylthio-D-ribose 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CCRF S-180 II cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-methylthioadenosine + phosphate | involved in salvage of adenine and methionine from 5'-methylthioadenosine | Mus musculus | adenine + 5-methylthio-D-ribose 1-phosphate | - |
? | |
5'-methylthioadenosine + phosphate | involved in salvage of adenine and methionine from 5'-methylthioadenosine | Homo sapiens | adenine + 5-methylthio-D-ribose 1-phosphate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | 0.0007 | 2-bromo-9-(1,3-dihydroxy-2-propoxymethyl)adenine | - |
Mus musculus | |
0.0002 | 0.0007 | 2-chloro-9-(1,3-dihydroxy-2-propoxymethyl)adenine | - |
Mus musculus | |
0.0002 | 0.0007 | 2-iodo-9-(1,3-dihydroxy-2-propoxymethyl)adenine | - |
Mus musculus | |
0.001 | 0.01 | 2-bromo-9-(2-hydroxyethoxymethyl)adenine | - |
Mus musculus | |
0.001 | 0.01 | 2-chloro-9-(2-hydroxyethoxymethyl)adenine | - |
Mus musculus | |
0.001 | 0.01 | 2-iodo-9-(2-hydroxyethoxymethyl)adenine | - |
Mus musculus | |
0.015 | - |
9-(phosphonoheptyl)adenine | low phosphate concentration of 3.5 mM | Mus musculus |