Application | Comment | Organism |
---|---|---|
medicine | possibility of targeting the enzyme in the design of an enzyme-selective therapy for patients with T-cell acute lymphoblastic leukemia and other enzyme-deficient malignancies | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-methylthioadenosine + phosphate | Homo sapiens | important for the salvage of adenine and methionine | adenine + 5-methylthio-D-ribose 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hematopoietic stem cell | and progenitor cells | Homo sapiens | - |
MOLT-4 cell | - |
Homo sapiens | - |
additional information | enzyme is deficient in patients with T-cell acute lymphoblastic leukemia, no activity in enzyme-deficient CEM cells | Homo sapiens | - |
peripheral blood | - |
Homo sapiens | - |
peripheral blood mononuclear cell | CD34+ erythroid burst-forming unit, granulocyte/monocyte colony-forming unit, granulocyte/erythrocyte/macrophage/megakaryocyte colony-forming unit progenitors and primitive high proliferative potential colony-forming cells in the purified CD34+ cells are cultured | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-methylthioadenosine + phosphate | - |
Homo sapiens | adenine + 5-methylthio-D-ribose 1-phosphate | - |
? | |
5'-methylthioadenosine + phosphate | important for the salvage of adenine and methionine | Homo sapiens | adenine + 5-methylthio-D-ribose 1-phosphate | - |
? |