Literature summary for 2.4.2.28 extracted from

Singh, V.; Shi, W.; Evans, G.B.; Tyler, P.C.; Furneaux, R.H.; Almo, S.C.; Schramm, V.L.
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A (2004), Biochemistry, 43, 9-18.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
X-ray structure with (1S)-1-(9-deazaadenin-9-yl)-1,4-di-deoxy-1,4-imino-5-methylthio-D-ribitol	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(1S)-1-(9-deazaadenin-9-yl)-1,4-di-deoxy-1,4-imino-5-methylthio-D-ribitol	-	Homo sapiens
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(4-chlorophe-nylthiomethyl)pyrrolidine	-	Homo sapiens
(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(methylthiomethyl)pyrrolidine	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.005	-	5'-methylthioadenosine	pH 7.0, 25°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q13126	recombinant	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5'-methylthioadenosine + phosphate	-	Homo sapiens	adenine + 5-methylthio-D-ribose 1-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
5'-methylthioadenosine phosphorylase	-	Homo sapiens
MTAP	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000036	-	(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(methylthiomethyl)pyrrolidine	pH 7.0, 25°C	Homo sapiens
0.0000013	-	(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(methylthiomethyl)pyrrolidine	pH 7.0, 25°C	Homo sapiens
0.00000175	-	(3R,4S)-1-[(9-deazaadenin-9-yl)methyl]-3-hydroxy-4-(methylthiomethyl)pyrrolidine	pH 7.0, 25°C	Homo sapiens
0.000026	-	(1S)-1-(9-deazaadenin-9-yl)-1,4-di-deoxy-1,4-imino-5-methylthio-D-ribitol	pH 7.0, 25°C	Homo sapiens

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Release 2023.1 (January 2023)